Seborrheic Keratosis
Article Sections
Introduction
Seborrheic keratoses (SKs) are classically brown hyperkeratotic papules or plaques with a warty and "stuck-on" appearance. They are common in older adults and are themselves benign. However, a sudden eruption of multiple SKs may be a sign of occult internal malignancy.
Risk factors
Factors that increase the risk of developing SKs include the following:
- Older age (age >50)
- Positive family history
- Light skin
- Pregnancy, estrogen replacement therapy
- Underlying malignancy, which can cause sudden onset of multiple SKs (Leser-Trélat sign)
Etiology
The etiology of SK is not fully understood; however, it is frequently associated with activating mutations of the fibroblast growth factor receptor 3 gene.
Clinical presentation
SKs classically develop in older adults and present as brown, hyperkeratotic papules or plaques with a warty and "
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